What are use, actions and side effects of Fluoxetine (Prozac, Fludac)

Fluoxetine is a SSRI or selective serotonin reuptake inhibitor class medication. It is mainly prescribed for clinical depression, anxiety disorders and OCD (Obsessive compulsive disorders). Prozac is the original brand name of this drug and Fludac is a popular brand in India. Main side effects are insomnia and sexual dysfunction.

What are the Fluoxetine (Prozac, Fludac) actions?

Fluoxetine inhibits serotonin reuptake pumps in certain neuronal connections. This action increases the naturally occurring serotonin neurotransmitter levels. Increased serotonin levels causes changes in gene expression, which ultimately do its intended therapeutic actions. However, increased serotonin in unwanted areas of the brain causes side effects.

Uses of Fluoxetine (Prozac, Fludac)

Fluoxetine is prescribed as a first line medication for clinical depression. In addition, it is prescribed for anxiety disorders such as generalized anxiety disorder, obsessive compulsive disorder, premenstrual dysphoric syndrome, and to treat premature ejaculation.

Usually Fluoxetine (Prozac, Fludac) is prescribed in lowest possible dose then it is increased until satisfactory symptom control is achieved. However, it is prescribed in little higher doses in OCD.

Most common side effects

Fluoxetine is known to cause disturbance of sleep or insomnia. Therefore, it is prescribed usually in the morning. It should not be taken in night. In addition, Fluoxetine (Prozac, Fludac) can cause sexual dysfunction. It includes lack of desire or libido and male erectile impotence. In fact, some studies have confirmed that around 80% of patients who take Fluoxetine (Prozac, Fludac) experience some form of sexual dysfunction. However, clinical depression is also known to cause sexual dysfunction. Treating depression should increase sexual function. Therefore, net effect would be the end result of above two factors.

Gastrointestinal problems such as nausea and vomiting are also common with Fluoxetine (Prozac, Fludac). In addition, Fluoxetine can cause rashes. Some patients can get allergic reactions such as anaphylaxis with this drug. In addition, some patients can get tremors, headache, dizziness, increased sweating and short term increase in anxiety.

Other side effects those are not so common

Some patients can get blood electrolyte imbalance, which can lead to increased risk of fits. Fluoxetine is also known to increase the risk of seizures. In addition, Fluoxetine can cause mania in patients with bipolar disorder.

Treating depression in adolescents and children with fluoxetine can increase the risk of suicide. In addition, several clinical trials have shown that people below 18 are not getting the full benefit of the fluoxetine therapy.

What are the rare side effects of fluoxetine?

Fluoxetine can cause problems with blood sugar control in patients with diabetes. In addition, it can cause pharyngitis. Some patients who take Fluoxetine (Prozac, Fludac) can get sudden drop in blood pressure associated with standing or postural drop. This can result in faintish attacks.

Summary

Fluoxetine is a SSRI class medication prescribed for clinical depression and various other psychiatric disorders. It can cause nausea, vomiting, insomnia and sexual dysfunction.

Sources

BNF

Disclaimer

Even though the author of this article is a Medical doctor, contents of this article are for information only. You should always consult your doctor, before starting or stopping Fluoxetine (Prozac, Fludac). In addition, medical information can change over time.